S87498 |
ML365 |
源叶(MedMol) | 98% |
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- 产品描述: ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels
- 靶点: IC50: 4 nM (TASK1/KCNK3), 390 nM (TASK3/KCNK9);PotassiumChannel
- 体外研究:
ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM
- 参考文献:
1. Zou B, et al. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. Probe Reports from the NIH Molecular Libraries Program [Internet].
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.775 ml 13.873 ml 27.747 ml 5 mM 0.555 ml 2.775 ml 5.549 ml 10 mM 0.277 ml 1.387 ml 2.775 ml 50 mM 0.055 ml 0.277 ml 0.555 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)