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• 产品描述： Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.

• 靶点： NADPH;Potassium Channel;PotassiumChannel; NADPH

• 参考文献：
  1. Gopalakrishnan M, et al. Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells. Br J Pharmacol. 2000 Apr;129(7):1323-32. 2. Imamura Y, et al. Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide. Life Sci. 2001 Sep 7;69(16):1947-55. 3. Aldawsari H, et al. Int J Pharm. 2013 Sep 10;453(2):315-21. 4. McMahon RE, et al. The nature of the metabolites of acetohexamide in the rat and in the human. J Pharmacol Exp Ther. 1965 Aug;149(2):272-9.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.083 ml	15.413 ml	30.826 ml
  5 mM	0.617 ml	3.083 ml	6.165 ml
  10 mM	0.308 ml	1.541 ml	3.083 ml
  50 mM	0.062 ml	0.308 ml	0.617 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *