| 产品描述： | TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment |
| 靶点： |
EC50: 2167 nM (Flag-TFEB nuclear translocation);Autophagy |
| 体内研究： |
The medium lethal dose (LD50) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats).Short-term oral administration of TFEB activator 1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain.Chronic administration of TFEB activator 1 (10 mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains. Animal Model: Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g Dosage: 10 mg/kg and 25 mg/kg Administration: Short-term oral administration; for 24 hours Result: Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain. |
| 参考文献： |
1. Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20°C |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.397 ml |
16.987 ml |
33.974 ml |
| 5 mM |
0.679 ml |
3.397 ml |
6.795 ml |
| 10 mM |
0.34 ml |
1.699 ml |
3.397 ml |
| 50 mM |
0.068 ml |
0.34 ml |
0.679 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京