• 产品描述： Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor

• 靶点： Thromboxane (TX) synthase;ProstaglandinReceptor

• 体外研究：
  azoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production.
  Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production.

• 体内研究：
  Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs.

• 参考文献：
  1. Patrignani P , Filabozzi P , Catella F , et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.[J]. journal of pharmacology & experimental therapeutics, 1984, 228(2):472-477.
  2. Yu S M , Wu T S , Teng C M . Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor[J]. British Journal of Pharmacology, 1994, 111(3).

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.722 ml	18.608 ml	37.216 ml
  5 mM	0.744 ml	3.722 ml	7.443 ml
  10 mM	0.372 ml	1.861 ml	3.722 ml
  50 mM	0.074 ml	0.372 ml	0.744 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *