• 产品描述： GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC50 of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC50 of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome

• 靶点： IC50: 0.6 μM (SARS-CoV PLpro)

• 体外研究：
  GRL0617 (0-50 μM；48 h) 在 SARS-CoV 感染的 Vero E6 细胞中表现出显著的抗病毒活性。 Cell Viability Assay Cell Line: Vero E6 cells Concentration: 0, 10, 20, 30, 40 and 50 μM Incubation Time: 48 hours Result: Showed significant antiviral activity in SARS-CoV infected Vero E6 cells with an EC50 value of 14.5 μM.

• 参考文献：
  1. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.285 ml	16.426 ml	32.853 ml
  5 mM	0.657 ml	3.285 ml	6.571 ml
  10 mM	0.329 ml	1.643 ml	3.285 ml
  50 mM	0.066 ml	0.329 ml	0.657 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=14.903] Yang Yi et al."Schaftoside inhibits 3CLpro and PLpro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19."Acta Pharmaceutica Sinica B.2022 Aug;:

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *