• 产品描述： CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects

• 靶点： Camptothecins

• 体内研究：
  CL2A-SN-38 偶联抗 Trop-2 人源化抗体 hRS7 (腹腔注射，0.2或0.4mg/kg，每周2次，4周) 均能显著抑制人结肠 (COLO 205) 或胰腺小鼠肿瘤异种移植物模型的肿瘤生长 (Capan-1)

• 参考文献：
  1. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. 2. Thomas M Cardillo, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	0.676 ml	3.379 ml	6.758 ml
  5 mM	0.135 ml	0.676 ml	1.352 ml
  10 mM	0.068 ml	0.338 ml	0.676 ml
  50 mM	0.014 ml	0.068 ml	0.135 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=6.4] Ye Bi et al."Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy."Int J Nanomed. 2018; 13: 5811–5822

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *