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S87736

DIM-C-PPHOCH3

源叶(MedMol) 98%
  • 英文名:
  • 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
  • 别名:
  • CAS号:
  • 33985-68-1
  • 分子式:
  • C24H20N2O
  • 分子量:
  • 352.4284
  • 核磁/质谱:
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源叶(MedMol) S87736-5mg 98% ¥340.00元 5 - - - EA 加入购物车
源叶(MedMol) S87736-10mg 98% ¥544.00元 5 - - - EA 加入购物车
源叶(MedMol) S87736-25mg 98% ¥1088.00元 5 - - - EA 加入购物车
源叶(MedMol) S87736-100mg 98% ¥3050.00元 3 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 产品描述: DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
  • 靶点: Nur77
  • 体外研究:
    DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3
  • 体内研究:
    DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls
  • 参考文献:
    1. Cho SD, et al. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res. 2007 Jan 15;67(2):674-83.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: 2-8°C
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.837 ml 14.187 ml 28.375 ml
    5 mM 0.567 ml 2.837 ml 5.675 ml
    10 mM 0.284 ml 1.419 ml 2.837 ml
    50 mM 0.057 ml 0.284 ml 0.567 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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