• 产品描述： Aranidipine (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.

• 靶点： Calcium Channel;CalciumChannel

• 体内研究：
  At 1 and 6 h after oral administration of MPC-1304 (10 mg/kg) in spontaneously hypertensive rats (SHR), there was significant decrease (48%) in the number of [3H](+)-PN 200-110 binding sites (Bmax) in myocardial membranes compared to control values. The in vivo specific binding of [3H](+)-PN 200-110 in particulate fractions of aorta of SHR was significantly reduced (74.8 and 37.9%, respectively) at 1 and 6 after oral administration of MPC-1304 (3 mg/kg), while the myocardial [3H](+)-PN 200-110 binding was decreased only at 1 h later

• 参考文献：
  1. Nozawa Y, et al. Receptor occupation and pharmacokinetics of MPC-1304, a new Ca2+ channel antagonist, in spontaneously hypertensive rats. Eur J Pharmacol. 1995 Dec 12;287(2):191-6. 2. Masumiya H, et al. Inhibition of T-type and L-type Ca(2+) currents by aranidipine, a novel dihydropyridine Ca(2+) antagonist. Pharmacology. 2000 Aug;61(2):57-61.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.575 ml	12.874 ml	25.749 ml
  5 mM	0.515 ml	2.575 ml	5.15 ml
  10 mM	0.257 ml	1.287 ml	2.575 ml
  50 mM	0.051 ml	0.257 ml	0.515 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *