Qstatin

    
98%

Qstatin

源叶(MedMol)
S87750 一键复制产品信息
902688-24-8
C7H5BrN2O2S2
293.16
货号 规格 价格 上海 北京 武汉 南京 购买数量
S87750-5mg 98% ¥360.00 6 - - -
S87750-10mg 98% ¥560.00 7 - - -
S87750-25mg 98% ¥800.00 6 - - -
S87750-50mg 98% ¥1440.00 5 - - -
S87750-100mg 98% ¥2400.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species( SmcR with an EC50 of 208.9 nM).

产品描述: QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species( SmcR with an EC50 of 208.9 nM).
靶点: Antibacterial
体外研究: Because 377B6 [1-(5-bromothiophene-2-sulfonyl)-1H-pyrazole](QStatin) showed the strongest inhibition of SmcR activity without significant growth attenuation of V. vulnificus. SmcR activity was assessed by measuring the RLU level for V. vulnificus WT (pBB1) in the presence of different concentrations of QStatin, which revealed that the half-maximal effective concentration (EC50) of QStatin was 208.9 nM.
细胞实验: The plasmid pBB1 carrying the LuxRVh homologue-activated lux operon was conjugally transferred into the V. vulnificus wild-type (WT) strain, the ΔsmcR mutant, or the ΔluxO mutant. These V. vulnificus reporter strains were grown overnight, diluted 1:1,000 in fresh LBS, and treated with hit molecules. RLU values were calculated every hour. To determine the EC50, QStatin (10^12 to 10^4 M) or 2% DMSO as a control was added to the V. vulnificus WT reporter strain and RLU was measured after 5 h. The percentage of SmcR activity of the sample at a given concentration of QStatin was determined using the following equation: percent SmcR activity = sample RLU/control RLU × 100. The EC50 of QStatin (the concentration reducing the SmcR activity to 50%) was calculated from a plot of the percentages of SmcR activity versus QStatin concentrations using GraphPad Prism 6.0.
参考文献: 1. Kim B S , Jang S Y , Bang Y J , et al. QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species[J]. mBio, 2018, 9(1).
溶解性: Soluble  in  DMSO
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.411 ml 17.056 ml 34.111 ml
5 mM 0.682 ml 3.411 ml 6.822 ml
10 mM 0.341 ml 1.706 ml 3.411 ml
50 mM 0.068 ml 0.341 ml 0.682 ml
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参考文献

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