• 产品描述： Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats

• 靶点： A1R:1 nM (Ki);Adenosine A3 receptor:200 nM (Ki);A2AR:398 nM (Ki);AdenosineReceptor

• 体内研究：
  Derenofylline (0.3-10 mg/kg, oral administration) suppresses adenosine-induced bradycardia in rats. Derenofylline (10 mg/kg/d, oral administration, 12 weeks) reduces myocardial fibrosis in 5/6 nephrectomy rats without affecting blood pressure. Derenofylline (0.1-5mg/kg, intravenous injection) causes no major haemodynamic effects (heart rate and blood pressure). Animal Model: 5/6 nephrectomy rats Dosage: 10 mg/kg/d Administration: Oral administration, mixed with food for 12 weeks Result: Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.

• 参考文献：
  1. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32. 2. Marta Mateus, et al. Understanding the Role of Adenosine Receptors in the Myofibroblast Transformation in Peyronie's Disease. J Sex Med. 2018 Jul;15(7):947-957.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.243 ml	16.214 ml	32.427 ml
  5 mM	0.649 ml	3.243 ml	6.485 ml
  10 mM	0.324 ml	1.621 ml	3.243 ml
  50 mM	0.065 ml	0.324 ml	0.649 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *