| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 南京 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87833-5mg一口价 |
98.40% | ￥416.00 ￥332.00 |
5 | - | - | - | - |
|
S87833-10mg一口价 |
98.40% | ￥636.00 ￥508.00 |
6 | - | - | - | - |
|
S87833-25mg |
98.40% | ￥1270.00 |
6 | - | - | - | - |
|
S87833-50mg |
98.40% | ￥2040.00 |
4 | - | - | - | - |
|
S87833-100mg |
≥98% | ￥3650.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM) | ||||||||||||||||||||
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| 靶点： | Sigma receptor;Sigmareceptor | ||||||||||||||||||||
| 体内研究： | The pretreatment of Anavex 2-73 (1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Anavex 2-73 (>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency. The Anavex 2-73 (1mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Anavex 2-73 (0.1/1mg/kg). Seven days after injections, Anavex 2-73 attenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1mg/kg) | ||||||||||||||||||||
| 动物实验： | Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100μL/20g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures. | ||||||||||||||||||||
| 参考文献： | 1. Valentine Lahmy, et al. Blockade of Tau Hyperphosphorylation and Aβ1-42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic andσ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer's Disease. Neuropsychopharmacology. 2013 Aug; 38(9): 1706-1723. 2. Villard V, et al. Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J Psychopharmacol. 2011 Aug;25(8):1101-17. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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