• 产品描述： UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.

• 靶点： IC50: 0.66 μM (EAAT1);transporter

• 体外研究：
  UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048)

• 参考文献：
  1. Abrahamsen B, et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33(3):106

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃;干燥

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.367 ml	11.835 ml	23.67 ml
  5 mM	0.473 ml	2.367 ml	4.734 ml
  10 mM	0.237 ml	1.183 ml	2.367 ml
  50 mM	0.047 ml	0.237 ml	0.473 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *