Hoechst 34580

    
95%

Hoechst 34580

源叶(MedMol)
S87962 一键复制产品信息
23555-00-2
C27H29N7
451.5661
货号 规格 价格 上海 北京 武汉 南京 购买数量
S87962-5mg 95% ¥319.60 货期:2-3天 - - -
S87962-10mg 95% ¥430.00 4 - - -
S87962-25mg 95% ¥760.00 3 - - -
S87962-100mg 95% ¥2040.00 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.

产品描述: Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
靶点: Beta Amyloid;BetaAmyloid
体外研究: Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.
参考文献: 1. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.215 ml 11.073 ml 22.145 ml
5 mM 0.443 ml 2.215 ml 4.429 ml
10 mM 0.221 ml 1.107 ml 2.215 ml
50 mM 0.044 ml 0.221 ml 0.443 ml
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参考文献

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摩尔浓度计算器

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