货号	规格	价格	上海	北京	珠海	南京	武汉
S87962-5mg	95.00%	￥300.00 S87962-5mg ￥300.00 现货	4 4	-	-	-	-
S87962-10mg	95.00%	￥430.00 S87962-10mg ￥430.00 现货	4 4	-	-	-	-
S87962-25mg	95.00%	￥760.00 S87962-25mg ￥760.00 现货	2 2	-	-	-	-
S87962-100mg	95.00%	￥1850.00 S87962-100mg ￥1850.00 现货	3 3	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.

靶点：

Beta Amyloid;BetaAmyloid

体外研究：

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.

参考文献：

1. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.215 ml	11.073 ml	22.145 ml
5 mM	0.443 ml	2.215 ml	4.429 ml
10 mM	0.221 ml	1.107 ml	2.215 ml
50 mM	0.044 ml	0.221 ml	0.443 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置