S88056 |
CP 376395 |
源叶(MedMol) | 98% |
- 产品描述: CP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.
- 靶点: CRFR
- 体内研究:
Pretreatment with CP 376395 (ID50=17.8 mg/kg, p.o.) reverses the excitation of locus coeruleus neurons induced by icv CRF (3 μg) completely blocked the enhanced startle response, while pretreatment with CP 376395(10 mg/kg, p.o.) induced by icv CRF (1 μg) is partially blocked.
- 动物实验: Beagle dogs weighing between 8 and 15 kg are administered with CP 376395 hydrochloride salt (1.0 mg/kg) into the cephalic vein of the foreleg. Beagle dogs are treated with CP 376395(10 mg/mL) prepared in 0.1% methyl cellulose at pH 2 by oral.
- 参考文献:
1. Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92.
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.755 ml 13.777 ml 27.553 ml 5 mM 0.551 ml 2.755 ml 5.511 ml 10 mM 0.276 ml 1.378 ml 2.755 ml 50 mM 0.055 ml 0.276 ml 0.551 ml
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输入产品批号:
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)