S88068 |
JANEX-1 |
源叶(MedMol) | 98% |
- 产品描述: JANEX-1 (WHI-P131)是JAK3小分子抑制剂,选择性抑制JAK3,IC50为78 μM。它不影响JAK1或JAK2,及其他蛋白酪氨酸激酶的活性(IC50 ≥ 350 µM)
- 靶点: JAK3(Cell-free assay):78 μM;JAK
- 体内研究:
JANEX-1 is very well tolerated by mice and monkeys and effective plasma concentrations of JANEX-1 could be achieved at nontoxic dose levels. JANEX-1 suppresses the mitogen and antigen responses of T-cells and attenuates the severity of T-cell-dependent graft-versus-host disease in a bone marrow transplantation model
- 动物实验: Animal Models: Female NOD mice Dosages: 20, 50 and 100 mg/kg/day Administration: IP
- 参考文献:
1. Cetkovic-Cvrlje M, et al. Clin Immunol. 2003, 106(3):213-25. 2. Lv N, et al. Exp Cell Res. 2009, 315(12):2064-71. 3. E A Sudbeck, et al. Clin Cancer Res . 1999 Jun;5(6):1569-82.
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 3.363 ml 16.817 ml 33.635 ml 5 mM 0.673 ml 3.363 ml 6.727 ml 10 mM 0.336 ml 1.682 ml 3.363 ml 50 mM 0.067 ml 0.336 ml 0.673 ml
- 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
输入产品批号:
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)