货号	规格	价格	上海	北京	武汉	南京
S88098-2mg	≥98%	￥50.00 S88098-2mg ￥50.00 现货	10 10	-	-	-
S88098-5mg	≥98%	￥80.00 S88098-5mg ￥80.00 现货	12 >10	-	-	-
S88098-10mg	≥98%	￥120.00 S88098-10mg ￥120.00 现货	15 >10	-	-	-
S88098-25mg	≥98%	￥190.00 S88098-25mg ￥190.00 现货	4 4	-	-	-
S88098-50mg	≥98%	￥280.00 S88098-50mg ￥280.00 现货	4 4	-	-	-
S88098-100mg	≥98%	￥420.00 S88098-100mg ￥420.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

BQCA a highly selective allosteric modulator of the M1 mAChR.

产品描述：

BQCA a highly selective allosteric modulator of the M1 mAChR.

靶点：

mAChR;AChR

体内研究：

BQCA requires M1 to promote inositol phosphate turnover in primary neurons and to increase c-fos and arc RNA expression and ERK phosphorylation in the brain. BQCA reverses scopolamine-induced memory deficits in contextual fear conditioning, increases blood flow to the cerebral cortex, and increases wakefulness while reducing delta sleep. BQCA induces β-arrestin recruitment to M1, suggesting a role for this signal transduction mechanism in the cholinergic modulation of memory. BQCA increases firing of mPFC pyramidal cells in vivo. BQCA also restores discrimination reversal learning in a transgenic mouse model of Alzheimer's disease

参考文献：

1. Ma L, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15950-5. 2. Shirey JK, et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptorincreases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009 Nov 11;29(45):14271-86.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.233 ml	16.164 ml	32.329 ml
5 mM	0.647 ml	3.233 ml	6.466 ml
10 mM	0.323 ml	1.616 ml	3.233 ml
50 mM	0.065 ml	0.323 ml	0.647 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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