| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S88098-2mg |
98.0% | ￥176.80 | 10 | - | - | - |
|
S88098-5mg |
98.0% | ￥306.00 | >10 | - | - | - |
|
S88098-10mg |
98.0% | ￥442.00 | >10 | - | - | - |
|
S88098-25mg |
98.0% | ￥952.00 | 4 | - | - | - |
|
S88098-50mg |
98.0% | ￥1632.00 | 4 | - | - | - |
|
S88098-100mg |
≥98% | ￥2900.00 | 货期：2-3天 | - | - | - |
|
BQCA a highly selective allosteric modulator of the M1 mAChR.
| 产品描述： | BQCA a highly selective allosteric modulator of the M1 mAChR. | ||||||||||||||||||||
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| 靶点： | mAChR;AChR | ||||||||||||||||||||
| 体内研究： | BQCA requires M1 to promote inositol phosphate turnover in primary neurons and to increase c-fos and arc RNA expression and ERK phosphorylation in the brain. BQCA reverses scopolamine-induced memory deficits in contextual fear conditioning, increases blood flow to the cerebral cortex, and increases wakefulness while reducing delta sleep. BQCA induces β-arrestin recruitment to M1, suggesting a role for this signal transduction mechanism in the cholinergic modulation of memory. BQCA increases firing of mPFC pyramidal cells in vivo. BQCA also restores discrimination reversal learning in a transgenic mouse model of Alzheimer's disease | ||||||||||||||||||||
| 参考文献： | 1. Ma L, et al. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15950-5. 2. Shirey JK, et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptorincreases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009 Nov 11;29(45):14271-86. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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