• 产品描述： Bay K 8644是一种高选择性的L型钙离子通道激动剂，EC50为17.3 nM

• 靶点： L-type calcium channel(in the isolated field-stimulated vas deferens of the mouse):17.3nM(EC50);CalciumChannel

• 体外研究：
  Bay K 8644 作为L型钙离子的激动剂，提高了取自大鼠的肠系膜动脉的静息张力

• 体内研究：
  Bay K 8644 可诱导5周龄、3月龄、1年、1.5年龄wistar-kyoto大鼠主动脉的小的收缩，这一现象不受大鼠年龄所影响

• 细胞实验： Cell lines: 5TGM1 cells Concentrations: 10 nM Incubation Time: 30 minutes Method: Cells were treated with indicated concentration of drug for 30 minutes.

• 动物实验： Animal Models: Male Sprague-Dawley rats Dosages: 1, 10, 50 and 100 µg/kg Administration: Jugular catheters

• 参考文献：
  1. A J Gonzales,et al. Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens. Br J Pharmacol. 1989, 96(2):333-340 2. Sulayma A. Albarwani,et al. Aging Reduces L-Type Calcium Channel Current and the Vasodilatory Response of Small Mesenteric Arteries to Calcium Channel Blockers. Front Physiol. 2016, 7:171. 3. Hernández MC，et al. Effects of Bay K 8644 in aorta from spontaneously hypertensive and Wistar Kyoto rats of different ages. J Auton Pharmacol. 1995, 15(4):257-269. 4. Wang J, et al. Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis. ACS Nano. 2021 Sep 28;15(9):14360-14372. 5. Ives N, et al. BAY k 8644, a calcium channel agonist, reverses hypotension in endotoxin-shocked rats. Eur J Pharmacol. 1986 Nov 4;130(3):169-75.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.807 ml	14.033 ml	28.067 ml
  5 mM	0.561 ml	2.807 ml	5.613 ml
  10 mM	0.281 ml	1.403 ml	2.807 ml
  50 mM	0.056 ml	0.281 ml	0.561 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *