| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|
S88205-5mg促销 |
≥98% | ￥224.00 ￥200.00 |
3 | - | - | - |
|
S88205-10mg促销 |
≥98% | ￥370.00 ￥332.00 |
1 | - | - | - |
|
S88205-25mg促销 |
≥98% | ￥812.00 ￥730.00 |
5 | - | - | - |
|
S88205-50mg促销 |
≥98% | ￥1530.00 ￥1380.00 |
货期：3-5天 | - | - | - |
|
S88205-100mg促销 |
≥98% | ￥2340.00 ￥2110.00 |
1 | - | - | - |
|
S88205-250mg促销 |
≥98% | ￥3990.00 ￥3590.00 |
货期：3-5天 | - | - | - |
|
| 产品描述： | S1RA (E-52862)是一种选择性sigma-1 receptor (σ1R)拮抗剂，对人源σ1受体的结合亲和力Ki为17 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | σ1R:17 nM(Ki);Sigmareceptor | ||||||||||||||||||||
| 体外研究： | S1RA behaves as a highly selective σ1 receptor antagonist. It shows high affinity for human (Ki= 17 nM) and guinea pig (Ki= 23.5 nM) σ1 receptors but no significant affinity for the σ2 receptors (Ki > 1000 nM for guinea pig and rat σ2 receptors). It has moderate affinity (Ki= 328 nM) and antagonistic activity, with very low potency (IC50= 4700 nM) against human 5-HT2B receptor. S1RA shows no significant affinity (Ki > 1 µM or % inhibition at 1 µM < 50%) for other additional 170 targets (receptors, transporters, ion channels and enzymes) | ||||||||||||||||||||
| 体内研究： | S1RA crosses the blood-brain barrier and binds to σ1 receptors in the CNS | ||||||||||||||||||||
| 参考文献： | 1. L Romero, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol. 2012, 166(8): 2289–2306. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol、H2O | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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