• 产品描述： SGX523 is a exquisitely selective and ATP-competitive MET inhibitor. SGX523 potently inhibits MET with an IC50 of 4 nM and is >1,000-fold selective versus other protein kinases. Antitumor activity

• 靶点： c-Met/HGFR

• 体内研究：
  SGX523 exhibits antitumor activity in vivo. SGX523 inhibits MET-dependent tumor growth. Animal Model: Female Harlan nude mice (athymic nu/nu) were s.c. implanted with U87 cells Dosage: 10 or 30 mg/kg Administration: Oral gavage; twice daily starting at day 5 for 22 days Result: Potently inhibited U87MG tumor growth at a dose of 10 mg/kg administered twice daily.Led to clear regression of U87MG tumors at 30 mg/kg dosed twice daily.

• 参考文献：
  1. Buchanan SG, et al. SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther, 2009, 8(12), 3181-3190.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.782 ml	13.912 ml	27.824 ml
  5 mM	0.556 ml	2.782 ml	5.565 ml
  10 mM	0.278 ml	1.391 ml	2.782 ml
  50 mM	0.056 ml	0.278 ml	0.556 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *