• 产品描述： PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain

• 靶点： EpigeneticReaderDomain

• 体外研究：
  PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors

• 参考文献：
  1. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96.

• 溶解性： DMSO：100  mg  /  mL

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.904 ml	9.522 ml	19.045 ml
  5 mM	0.381 ml	1.904 ml	3.809 ml
  10 mM	0.19 ml	0.952 ml	1.904 ml
  50 mM	0.038 ml	0.19 ml	0.381 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *