• 产品描述： WM-8014是组蛋白乙酰基转移酶KAT6A的抑制剂，IC50为8 nM

• 靶点： KAT6A(Cell-free assay):8 nM;HistoneAcetyltransferase

• 体外研究：
  WM-8014 induces cell cycle arrest in embryonic day (E)14.5 mouse embryonic fibroblasts.Cells treated with WM-8014 failed to proliferate after ten days of treatment (IC50 2.4 μM). Higher doses of WM-8014 (up to 40 μM) did not accelerate growth arrest, which after eight days of treatment was irreversible

• 体内研究：
  WM-8014 potentiates oncogene-induced senescence in a zebrafish model of hepatocellular carcinom

• 参考文献：
  1. Leaver DJ,et al. Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J Med Chem. 2019 8;62(15):7146-7159. 2. Baell JB,et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature.2018;560(7717):253-257.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.601 ml	13.007 ml	26.013 ml
  5 mM	0.52 ml	2.601 ml	5.203 ml
  10 mM	0.26 ml	1.301 ml	2.601 ml
  50 mM	0.052 ml	0.26 ml	0.52 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *