• 产品描述： HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM

• 靶点： IC50:20.8 nM (RIP3);RIPkinase

• 体外研究：
  HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines. HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation. HS-1371 (0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death. Western Blot Analysis Cell Line: HT-29 cells Concentration: 0.1, 1, 5, 10, 20 μM Incubation Time: 9 hours Result: Showed an inhibitory effect on S227 auto-phosphorylation of RIP3

• 参考文献：
  1. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.601 ml	13.005 ml	26.01 ml
  5 mM	0.52 ml	2.601 ml	5.202 ml
  10 mM	0.26 ml	1.3 ml	2.601 ml
  50 mM	0.052 ml	0.26 ml	0.52 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *