4-Octyl Itaconate

    
98%

Butanedioic acid, methylene-, 4-octyl ester

源叶(MedMol)
S88644 一键复制产品信息
3133-16-2
C13H22O4
242.31138
4-Octyl Itaconate ;衣康酸盐
货号 规格 价格 上海 北京 武汉 南京 购买数量
S88644-10mg 98% ¥149.60 1 - - -
S88644-50mg 98% ¥408.00 2 - - -
S88644-100mg 98% ¥680.00 4 - - -
S88644-1g 98% ¥3500.00 1 - - -
产品介绍 参考文献(3篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

4-Octyl Itaconate激活Nrf2信号,在人类巨噬细胞和分离自全身性红斑狼疮患者的PBMC中抑制促炎性因子的产生

产品描述: 4-Octyl Itaconate激活Nrf2信号,在人类巨噬细胞和分离自全身性红斑狼疮患者的PBMC中抑制促炎性因子的产生
靶点: Nrf2
体外研究: 4-Octyl Itaconate effectively prevents NP cells from degeneration through anti-ROS and anti-inflammation, and the combined use with tBHQ has better effects
体内研究: 4-Octyl itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and modulate type I interferons
细胞实验: Cell lines: nucleus pulposus (NP) cells Concentrations: 5, 10, 15, 20, 25, 30 µM Incubation Time: 24 h Method: The NP cells are cultured in the 24 well plates with a density of 1.5×104 per well. To test the optimized concentration of tBHQ, 4-Octyl Itaconate, and the mixture of them, ranged concentration of drugs is used to stimulate NP cells for 24 hours. The highest concentration that did not affect the cell viability is applied in our experiment. Besides, we also used Lipopolysaccharides to induce NP cell degeneration.
动物实验: Animal Models: C57BL/6 mice Dosages: 50 mg/kg Administration: i.p.
参考文献: 1. Zhong WX, et al. The effect of Nrf2 activators tBHQ and 4-octyl itaconate on the nucleus pulposus cell degeneration. Eur Rev Med Pharmacol Sci. 2021 Aug;25(16):5189-5198. 2. Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117.
溶解性: Soluble  in  DMSO、Ethanol
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 4.127 ml 20.635 ml 41.269 ml
5 mM 0.825 ml 4.127 ml 8.254 ml
10 mM 0.413 ml 2.063 ml 4.127 ml
50 mM 0.083 ml 0.413 ml 0.825 ml
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