• 产品描述： FOY251 是 camostat mesilate 的活性代谢产物，是 synthetic serine protease 的抑制剂。 FOY251 可抑制 SARS-CoV-2 感染

• 靶点： synthetic serine protease;Serine/threoninkinase; SARS-CoV

• 体内研究：
  FOY-251 increases the circulating levels of FGF21 of transcription and plasma are maintained with induction of liver integrated stress response (ISR) transcription target genes up to 1 wk of treatment in both ob/ob and lean mice, also increases plasma FGF21 levels when dosed to DIO mice.

• 细胞实验： Cell lines: Mouse cortical collecting duct cell line (M-1 cells) Concentrations: 0.01–10 μM Incubation Time: 24 h Method: M-1 cells were cultured on semi-permeable membrane, serum deprived for 24 h, and treated with 0.01-1 μM camostat mesilate or 0.01-10 μM FOY-251 from the apical side. After 24 h incubation, transepithelial voltage (Vte) and resistance (Rte) were measured with a volt ohm meter. Ieq was determined as the ratio of Vte to Rte and was normalized by dividing Ieq by the surface area (113 mm2 ) of active membrane.

• 动物实验： Animal Models: Male ob/ob mice, lean and diet-induced obese (DIO) C57BL/6 mice Dosages: 0.8 mg/g food Administration: p.o.

• 参考文献：
  1. Ai Maekawa, et al. J Hypertens. 2009 Jan;27(1):181-9. 2. Markus Hoffmann, et al. bioRxiv. 2020 Aug 5;2020.08.05.237651. 3. Albarazanji, Kamal et al. American journal of physiology. Gastrointestinal and liver physiology vol. 316,5 (2019): G653-G667.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.443 ml	12.213 ml	24.425 ml
  5 mM	0.489 ml	2.443 ml	4.885 ml
  10 mM	0.244 ml	1.221 ml	2.443 ml
  50 mM	0.049 ml	0.244 ml	0.489 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *