S89122 |
BAMB-4 |
| 源叶(MedMol) | 98% |
- 产品描述： BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer
- 靶点： IC50: 37 μM (ITPKA); 20 μM (InsP3 kinase)
- 体外研究：
BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased Vmax. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity
- 参考文献：
1. Dominik Schröder, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 3.964 ml 19.82 ml 39.64 ml 5 mM 0.793 ml 3.964 ml 7.928 ml 10 mM 0.396 ml 1.982 ml 3.964 ml 50 mM 0.079 ml 0.396 ml 0.793 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
