• 产品描述： BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer

• 靶点： IC50: 37 μM (ITPKA); 20 μM (InsP3 kinase)

• 体外研究：
  BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased Vmax. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity

• 参考文献：
  1. Dominik Schröder, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.964 ml	19.82 ml	39.64 ml
  5 mM	0.793 ml	3.964 ml	7.928 ml
  10 mM	0.396 ml	1.982 ml	3.964 ml
  50 mM	0.079 ml	0.396 ml	0.793 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *