• 产品描述：

  BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively)

• 靶点： Neuropeptide Y Receptor;NeuropeptideYReceptor

• 体外研究：
  BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting. BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY. BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels. Animal Model: Adult male Chbb:Thom rats weighing between 300 and 340g Dosage: 30 μg Administration: bilateral paraventricular nucleus injection Result: Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding. Animal Model: 7-week-old C57BL/6JAusb mice Dosage: 0.5 μM Administration: p.o. Result: Significantly increased serum insulin levels.

• 参考文献：
  1. Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125(3):549-55. 2. Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.554 ml	7.768 ml	15.536 ml
  5 mM	0.311 ml	1.554 ml	3.107 ml
  10 mM	0.155 ml	0.777 ml	1.554 ml
  50 mM	0.031 ml	0.155 ml	0.311 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *