• 产品描述： CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553)是一种有效的 CD38 抑制剂，对人CD38和小鼠CD38的IC50分别为7.3 nM和1.9 nM

• 靶点： mCD38(Cell-free assay):1.9 nM; hCD38(Cell-free assay):7.3 nM;CD38

• 体外研究：
  CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs

• 体内研究：
  CD38 inhibitor 1 (compound 78c) is found to not only be a very potent inhibitor, but also had suitable physiochemical properties to serve as a robust tool for in vivo studies. In addition, CD38 inhibitor 1 (compound 78c) is able to elevate NAD in both liver and gastrocnemius tissue when dosed orally in a DIO mouse

• 细胞实验： Cell lines: HEK293T, MEFs, A549, Jurkat T and AML12 cells Concentrations: 0.5 μM, 0.2 - 0.5 μM Incubation Time: 16 h, 24 h Method: To test the reversibility of the CD38i, A549 cells were treated with vehicle or 0.5 μM 78c for 16 hours. Then, cells were washed and incubated with (78c) or without (78c+release) 78c for another 8 hours.

• 动物实验： Animal Models: DIO C57Bl6 mice Dosages: 30 mg/kg, 2 mg/kg Administration: Oral gavage, IV

• 参考文献：
  1. Curt D Haffner, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71. 2. Mariana G Tarragó, et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018 May 1;27(5):1081-1095.e10.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.418 ml	12.091 ml	24.182 ml
  5 mM	0.484 ml	2.418 ml	4.836 ml
  10 mM	0.242 ml	1.209 ml	2.418 ml
  50 mM	0.048 ml	0.242 ml	0.484 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *