• 产品描述： BMS-P5 is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model

• 靶点： PAD

• 体外研究：
  BMS-P5 blocks calcium ionophore-induced citrullination of histone H3. BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM. Cell Viability Assay Cell Line: Neutrophils. Concentration: 10 µM and 100 µM. Incubation Time: 30 min followed by addition of DP42 or 5TGM1 CM. Result: Prevented MM-induced NET formation.

• 体内研究：
  BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice. BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression. Animal Model: Syngeneic mouse model of MM. Dosage: 50 mg/kg. Administration: Oral gavage, twice a day beginning on day 3 after tumor cell injection. Result: Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.

• 参考文献：
  1. Marina Li, et al. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19(7):1530-1538.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.964 ml	9.822 ml	19.644 ml
  5 mM	0.393 ml	1.964 ml	3.929 ml
  10 mM	0.196 ml	0.982 ml	1.964 ml
  50 mM	0.039 ml	0.196 ml	0.393 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *