• 产品描述： UNC6934是一种靶向NSD2的N端PWWP(PWWP1)结构域(NSD2-PWWP1)的化学探针。UNC6934是一种有效的NSD2-PWWP1拮抗剂，Kd（SPR）为80 nM，对NSD2-PWWP1的选择性高于其他14个PWWP结构域，包括NSD3-PWWP1。 UNC6934破坏了NSD2-PWWP1与U2OS细胞中H3K36me2核小体的相互作用，NanoBret assay测得IC50为1.09 μM

• 靶点： UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.;HistoneMethyltransferase

• 体外研究：
  UNC6934-mediated antagonism of PWWP1 leads to accumulation of endogenous NSD2 in the nucleolus

• 细胞实验： Cell lines: U2OS cells Concentrations: 5 μM Incubation Time: 4 h Method: U2OS cells are treated for 4 h with DMSO vehicle control or 5 μM UNC6934. Confocal microscopy is used to observe the intracellular NSD2 and fibrillarin staining. Quantification of colocalization between NSD2 and the nucleolar marker fibrillarin as determined by Pearson correlation coefficient (PCC).

• 参考文献：
  1. Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2022 Jan;18(1):56-63.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.255 ml	11.275 ml	22.55 ml
  5 mM	0.451 ml	2.255 ml	4.51 ml
  10 mM	0.226 ml	1.128 ml	2.255 ml
  50 mM	0.045 ml	0.226 ml	0.451 ml

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• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *