• 产品描述： Xeruborbactam (QPX7728) is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam inhibits key serine and metallo beta-lactamases at a nano molar range

• 靶点： Beta-lactamase

• 体外研究：
  Xeruborbactam is a potent inhibitor of Class D carbapenemases from A. baumannii.
  Xeruborbactam is minimally affected by the activity of major MDR efflux pumps from P. aeruginosa, representing a significant improvement over the earlier generation boronate beta-lactamase inhibitor (BLI) vaborbactam.
  The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate Xeruborbactam is a useful inhibitor for use with multiple beta-lactam antibiotics.

• 参考文献：
  1. Lomovskaya O, et al, The Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Antimicrob Agents Chemother. 2020 Mar 30. pii: AAC.00552-20.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃，避光

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	4.505 ml	22.525 ml	45.049 ml
  5 mM	0.901 ml	4.505 ml	9.01 ml
  10 mM	0.45 ml	2.252 ml	4.505 ml
  50 mM	0.09 ml	0.45 ml	0.901 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *