WAY-213613 hydrochloride

    
98%

源叶(MedMol)
S89446 一键复制产品信息
868359-05-1(free base)
C16H14BrClF2N2O4
451.65
货号 规格 价格 上海 北京 武汉 南京 购买数量
S89446-5mg 98% ¥1500.00 货期:3-5天 - - -
S89446-10mg 98% ¥2000.00 货期:3-5天 - - -
S89446-25mg 98% ¥4500.00 货期:3-5天 - - -
S89446-100mg 98% ¥12000.00 货期:3-5天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system

产品描述: WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system
靶点: EAAT2;transporter
体外研究: WAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC50 values of 5004 nM, 85 nM and 3787 nM, respectively. WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[3H] glutamate uptake with Ki values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively. WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC50 values of 48, 0.13 and 4.0 μM, respectively. WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses
参考文献: 1. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. 2. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.214 ml 11.071 ml 22.141 ml
5 mM 0.443 ml 2.214 ml 4.428 ml
10 mM 0.221 ml 1.107 ml 2.214 ml
50 mM 0.044 ml 0.221 ml 0.443 ml
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参考文献

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