货号	规格	价格	上海	北京	珠海	武汉
S89479-5mg	≥98%	￥210.00 S89479-5mg ￥210.00 现货	100 >10	-	-	-
S89479-10mg	≥98%	￥340.00 S89479-10mg ￥340.00 现货	50 >10	-	-	-
S89479-25mg	≥98%	￥700.00 S89479-25mg ￥700.00 现货	20 >10	-	-	-
S89479-100mg	≥98%	￥1700.00 S89479-100mg ￥1700.00 现货	5 5	-	-	-

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产品描述：

GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator.

靶点：

GPR

体外研究：

The long-chain fatty acid receptor FFAR1/GPR40 binds agonists in both an interhelical site between the extracellular segments of transmembrane helix (TM)-III and TM-IV and a lipid-exposed groove between the intracellular segments of these helices. Molecular dynamics simulations of FFAR1 with agonist removed demonstrated a major rearrangement of the polar and charged anchor point residues for the carboxylic acid moiety of the agonist in the interhelical site, which was associated with closure of a neighboring, solvent-exposed pocket between the extracellular poles of TM-I, TM-II, and TM-VII. A synthetic compound designed to bind in this pocket, and thereby prevent its closure, was identified through structure-based virtual screening and shown to function both as an agonist and as an allosteric modulator of receptor activation

参考文献：

1. Lückmann M, et al. Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7123-7128.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.568 ml	12.84 ml	25.68 ml
5 mM	0.514 ml	2.568 ml	5.136 ml
10 mM	0.257 ml	1.284 ml	2.568 ml
50 mM	0.051 ml	0.257 ml	0.514 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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