• 产品描述： Rottlerin (Mallotoxin, NSC 56346, NSC 94525)是一种从 Mallotus Philippinensis 纯化出来的天然化合物，一种特效的 Protein kinase 的抑制剂，对PKCδ(来自杆状病毒感染的Sf9昆虫细胞)、PKCδ(来自猪脾)和CaM kinase III的IC50值分别为3 μM、6 μM和5.3 μM。Rottlerin 还可以抑制PKCα、PKCγ、PKCβ、PKCη、CKII和PKA，其IC50值分别为30 μM、40 μM、42 μM、82 μM、30 μM和78 μM

• 靶点： PKCδ(Cell-free assay):3 μM; CKIII(Cell-free assay):5.3 μM; PKCα(Cell-free assay):30 μM; CKII(Cell-free assay):30 μM; PKCγ(Cell-free assay):40 μM;PKCβ(Cell-free assay):42 μM;PKA(Cell-free assay):78 μM;PKCη(Cell-free assay):82 μM;CaMK; Apoptosis; Others; HIVProtease; PKA; PKC; Autophagy

• 体内研究：
  A xenograft model of pancreatic cancer is prepared by injection of 2×106 HPAF-II cells subcutaneously into nude mice. A substantial amount of Rottlerin is detected in tumor and plasma in mice fed Rottlerin diet. These data indicate that Rottlerin is efficiently absorbed in vivo and suggest a strong potential for Rottlerin as a preventive or adjuvant supplement for pancreatic cancer.

• 细胞实验： Cell lines: HPAF-II cells Concentrations: 25 μM Incubation Time: 3 h, 24 h Method: The accumulation of Rottlerin is examined in HPAF-II cells treated with 25 μM Rottlerin, and the fate of Rottlerin in the incubation media. Cells are collected at 3 and 24 h after Rottlerin stimulation and conditioned media are taken at 0.5, 1.0, 3.0, 6.0 and 24 h (n=4 for each time point). Samples are prepared immediately for HPLC analysis without further storage.

• 动物实验： Animal Models: nude mice injected with HPAF-II cells Dosages: 120 mg/kg Administration: Oral gavage

• 参考文献：
  1. M Gschwendt, et al. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8. 2. Qing-Yi Lu, et al. J Chromatogr Sep Tech. 2013 Jan 1;4(1):100062.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.936 ml	9.68 ml	19.36 ml
  5 mM	0.387 ml	1.936 ml	3.872 ml
  10 mM	0.194 ml	0.968 ml	1.936 ml
  50 mM	0.039 ml	0.194 ml	0.387 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=10.8] Wei Ji et al."Hydrogel-encapsulated medium chain lipid-modified zeolite imidazole framework-90 as a promising platform for oral delivery of proteins."JOURNAL OF CONTROLLED RELEASE.2024 Mar;367:93

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *