• 产品描述： Astragaloside VI could activate EGFR/ERK signalling pathway to improve wound healing.

• 靶点： EGFR

• 体外研究：
  Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades

• 体内研究：
  Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats

• 参考文献：
  1. Lee SY, et al. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018 Jan 1;38:183-191. 2. Chen X, et al. Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades. Mol Neurobiol. 2018 Aug 7.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.056 ml	5.279 ml	10.558 ml
  5 mM	0.211 ml	1.056 ml	2.112 ml
  10 mM	0.106 ml	0.528 ml	1.056 ml
  50 mM	0.021 ml	0.106 ml	0.211 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 4. [6.7] Ruiqian Sun et al."Astragali Radix-Curcumae Rhizoma herb pair reduces the stemness of colorectal cancer cells through HIF-2α/β-catenin pathway."PHYTOMEDICINE.2024 Sep;132:155824

• 3. [IF=2.6] Qi Hongfei et al."Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells."CELL BIOCHEMISTRY AND BIOPHYSICS".2024 May;:1-10

• 2. Yuping Zhang, Shuyun Shi, Junfang Guo, Qingping You, Deshan Feng, On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali, Journal of Chromatography

• 1. 李洋洋,张苡铭,魏孔熙,周婷,何进鹏,丁楠,周谷城,史桐凡,柯宜诚,牛帆,刘永琦,张利英.黄芪不同有效成分对电离辐射致BMSCs DNA损伤防护作用的比较研究[J].中国药房,2020,31(24):2987-2992.

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *