货号	规格	价格	上海	北京	珠海	武汉
S89995-1mg	99.60%	￥150.00 S89995-1mg ￥150.00 现货	8 8	-	-	-
S89995-5mg	99.60%	￥390.00 S89995-5mg ￥390.00 现货	6 6	-	-	-
S89995-10mg	99.60%	￥650.00 S89995-10mg ￥650.00 现货	5 5	-	-	-
S89995-25mg	99.60%	￥1200.00 S89995-25mg ￥1200.00 现货	5 5	-	-	-
S89995-100mg	≥98%	￥3190.00 S89995-100mg ￥3190.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons

靶点：

D3 Receptor:38 nM (EC50);DopamineReceptor

体内研究：

In vivo pharmacokinetics experiments in mice (using 20 mg/kg; i.p.) reveals that ML417 is brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. ML417 displays a plasma Tmax of 0.5 hours and Cmax of 6500 ng/ml, and a brain Tmax of 0.25 hours and Cmax of 28000 ng/ml. Animal Model: 6-8 week old male C57BL/6 mice Dosage: 20 mg/kg Administration: I.p. (Pharmacokinetic Analysis) Result: Brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. Displayed a plasma Tmax of 0.5 hours and Cmax of 6500 ng/ml, and a brain Tmax of 0.25 hours and Cmax of 28000 ng/ml.

参考文献：

1. Moritz AE, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.635 ml	13.177 ml	26.354 ml
5 mM	0.527 ml	2.635 ml	5.271 ml
10 mM	0.264 ml	1.318 ml	2.635 ml
50 mM	0.053 ml	0.264 ml	0.527 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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