ML417

    
98%

ML417

源叶(MedMol)
S89995 一键复制产品信息
1386162-69-1
C₂₂H₂₅N₃O₃
379.45
货号 规格 价格 上海 北京 武汉 南京 购买数量
S89995-1mg 98% ¥285.60 10 - - -
S89995-5mg 98% ¥544.00 6 - - -
S89995-10mg 98% ¥938.40 5 - - -
S89995-25mg 98% ¥1632.00 5 - - -
S89995-100mg 98% ¥4624.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons

产品描述: ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons
靶点: D3 Receptor:38 nM (EC50);DopamineReceptor
体内研究: In vivo pharmacokinetics experiments in mice (using 20 mg/kg; i.p.) reveals that ML417 is brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. ML417 displays a plasma Tmax of 0.5 hours and Cmax of 6500 ng/ml, and a brain Tmax of 0.25 hours and Cmax of 28000 ng/ml. Animal Model: 6-8 week old male C57BL/6 mice Dosage: 20 mg/kg Administration: I.p. (Pharmacokinetic Analysis) Result: Brain penetrant and exhibits a plasma half-life of 3.44 hours and a brain half-life of 4.23 hours. Displayed a plasma Tmax of 0.5 hours and Cmax of 6500 ng/ml, and a brain Tmax of 0.25 hours and Cmax of 28000 ng/ml.
参考文献: 1. Moritz AE, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.635 ml 13.177 ml 26.354 ml
5 mM 0.527 ml 2.635 ml 5.271 ml
10 mM 0.264 ml 1.318 ml 2.635 ml
50 mM 0.053 ml 0.264 ml 0.527 ml
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参考文献

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