货号	规格	价格	上海	北京	珠海	重庆	武汉
T19220-1mg买3赠1	98.80%	￥320.00 T19220-1mg ￥320.00 现货（买3赠1）	5 5	-	-	-	-
T19220-5mg买3赠1	98.80%	￥600.00 T19220-5mg ￥600.00 现货（买3赠1）	4 4	-	-	-	-
T19220-10mg买3赠1	98.80%	￥900.00 T19220-10mg ￥900.00 现货（买3赠1）	5 5	-	-	-	-
T19220-25mg买3赠1	98.80%	￥2000.00 T19220-25mg ￥2000.00 现货（买3赠1）	4 4	-	-	-	-
T19220-100mg	98.80%	￥6000.00 T19220-100mg ￥6000.00 现货	1 1	-	-	-	-

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产品描述：

Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.

靶点：

IC50: 296 nM (GluR1), 296 nM (GluR1);Ki: 0.29 μM (GluR5Q);GluR; iGluR

体外研究：

Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2.

参考文献：

1. Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8.2. Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45(26):5745-54.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃ 氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.97 ml	9.851 ml	19.703 ml
5 mM	0.394 ml	1.97 ml	3.941 ml
10 mM	0.197 ml	0.985 ml	1.97 ml
50 mM	0.039 ml	0.197 ml	0.394 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

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分子摩尔量

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Philanthotoxin 74

(S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide dihydrochloride

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)