货号	规格	价格	上海	北京	珠海	南京	武汉
T21546-5mg一口价	98.60%	￥680.00 ￥544.00 T21546-5mg ￥544.00 现货	3 3	-	-	-	-
T21546-10mg	98.60%	￥1020.00 T21546-10mg ￥1020.00 现货	7 7	-	-	-	-
T21546-25mg	98.60%	￥2040.00 T21546-25mg ￥2040.00 现货	2 2	-	-	-	-
T21546-100mg	≥98%	￥5300.00 T21546-100mg ￥5300.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.

靶点：

pIC50: 7 (LXRα), 7.4 (LXRβ);LiverXReceptor

体外研究：

GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 dose-dependently suppresses basal transcription in full-length LXRα or full-length LXRβ cotransfection assays with IC50s of 17 nM and 9 nM, respectively. GSK2033 also effectively suppresses the transcription of an ABCA1 driven luciferase reporter dose-dependently displaying IC50s of 52 nM for LXRα and 10 nM for LXRβ. GSK2033 also suppresses the expression of both of fatty acid synthase (FASN) and SREBP1.

体内研究：

One month treatment of GSK2033 does not have significant effects on hepatic triglyceride levels. Plasma triglyceride levels are also unaffected by treatment with GSK2033.

参考文献：

1. Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6. 2. Griffett K, et al. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.69 ml	8.451 ml	16.902 ml
5 mM	0.338 ml	1.69 ml	3.38 ml
10 mM	0.169 ml	0.845 ml	1.69 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

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GSK 2033

2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)