• 产品描述： AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25

• 靶点： JNK;Apoptosis

• 体外研究：
  AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM. AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner. AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells. Apoptosis Analysis Cell Line: PC12 cells Concentration: 1, 2.5, 5, 10, 20, 40, 80 μM Incubation Time: 40 hours Result: Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM.Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM. Western Blot Analysis Cell Line: PC12 cells Concentration: 10, 20, 40 μM Incubation Time: 30 hours Result: Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein.

• 参考文献：
  1. Salehi AH, et, al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13(2):213-23.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.567 ml	17.837 ml	35.674 ml
  5 mM	0.713 ml	3.567 ml	7.135 ml
  10 mM	0.357 ml	1.784 ml	3.567 ml
  50 mM	0.071 ml	0.357 ml	0.713 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *