• 产品描述： VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%

• 靶点： Bacterial;Antibiotic

• 体外研究：
  VP-4604 (2.5 mM, 18 hours) inhibits drug-resistant S. aureus and P. aeruginosa with growth inhibiton (%) GI >95%. VP-4604 shows low cytotoxicity with a CC50 value >118.4 mM towards HEK-293 (human embryonic kidney) ATCC CRL‐1573 and an HC10 vaule >118.4 μM towards RBC (human red blood cells). VP-4604 (2.5 mM) is tolerated by mammalian cells (HaCaT, lymphocytes) with the inhibition growth (%) of 44.1% and >50%, respectively. Cell Proliferation Assay Cell Line: S. aureus ATCC25923, P. aeruginosa ATCC9027 Concentration: 0.625 mM, 1.25 mM, 2.5 mM Incubation Time: 18 hours Result: Showed antibacterial effect. Cell Cytotoxicity Assay Cell Line: HaCaT line (human keratinocytes), lymphocytes (from healthy adult human peripheral blood) Concentration: 0, 1, 10, 100, 1000, 2500 μM Incubation Time: 48 or 72 hours Result: Showed low toxicity towards mammalian cells.

• 参考文献：
  1. Vitalii Palchykov, et al. Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research. 2022. 31: 284-292.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.7 ml	18.498 ml	36.996 ml
  5 mM	0.74 ml	3.7 ml	7.399 ml
  10 mM	0.37 ml	1.85 ml	3.7 ml
  50 mM	0.074 ml	0.37 ml	0.74 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *