• 介绍：

   Gefitinib (ZD1839) 是一种有效，选择性和口服活性的 EGFR 酪氨酸激酶抑制剂，IC50 为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50 为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中 EGFR 自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，可用于癌症相关的研究，如肺癌和乳腺癌。

• 熔点： 119-120℃

• 沸点： 586.8℃

• 外观： 白色至米黄色粉末

• 溶解性： DMSO  :  125  mg/mL  (279.70  mM;  Need  ultrasonic)

• 储存条件： -20℃

• 用途： An EGFR-tyrosine kinase inhibitor

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 11. [IF=3.8] Xiaoping Song et al."Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF."TOXICOLOGY AND APPLIED PHARMACOLOGY".2024 Apr;:116938

• 10. [IF=7.2] Lei Zhang et al."Tanshinone IIA reverses gefitinib resistance in EGFR-mutant lung cancer via inhibition of SREBP1-mediated lipogenesis."PHYTOTHERAPY RESEARCH.2024 Jan;:

• 9. [IF=6.7] Song Xiaoping et al."Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC."ARCHIVES OF PHARMACAL RESEARCH.2023 Nov;:1-15

• 8. [IF=3.263] Lin Cao et al."Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase."Eur J Pharmacol. 2021 Jan;890:173647

• 7. [IF=4.22] Pang Jiafeng et al."Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib."J Mater Sci. 2018 Nov;53(21):14907-14921

• 6. Gu, Yanqiu, et al. "Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix." Acta Pharmaceutica Sinica B 10.10 (2020): 1856-186

• 5. Lin, Qing, et al. "Design of gefitinib-loaded poly (l-lactic acid) microspheres via a supercritical anti-solvent process for dry powder inhalation." International journal of pharmaceutics 532.1 (2017): 573-580.https://doi.org/10.1016/j.ijpharm.2017.09.051

• 4. Yanqiu, et al. "Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. " Journal of pharmaceutical and biomedical analysis 164

• 3. 吕昕,朱渊红,周林水,王真,刘正中.白花蛇舌草乙醇提取物联合吉非替尼对TGF-β_1诱导的肺腺癌细胞H358上皮间质化的干预作用[J].中国现代应用药学,2016,33(02):154-158.

• 2. 陈芝, 俞建东, 唐超园,等. 榄香烯注射液对吉非替尼在PC-9/GR细胞内转运动力学影响[J]. 中成药, 2018, 40(002):284-290.

• 1. 吕昕 周林水 陈瑞琳 等. shRNA干扰TTF-1基因对肺腺癌细胞EGFR-TKI敏感性及细胞上皮间质化的影响[J]. 浙江医学 2019 v.41(22):28-32+108.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *