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• 产品描述： BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1)是一种PD-1/PD-L1相互作用的小分子化合物抑制剂，IC50为6 nM

• 靶点： PD-1/PD-L1 interaction(Cell-free assay):0.006 μM;Apoptosis;PD-1/PD-L1

• 体外研究：
  PD-1/PD-L1 inhibitor 1 causes half-reduced cell viability at lower concentrations in triple-negative breast cancer (TNBC), activates ERK in MDA-MB-231 and MCF7, significantly increases IL-8 expression in MDA-MB-231 and HCC1806 when administrated in combination with ERK1/2 inhibitor, also potently downregulates the IL-8 expression to its half amount in MDA-MB-231

• 体内研究：
  PD-1/PD-L1 inhibitor 1 combined with Jiedu Sangen Decoction (JSD) remarkably inhibits and reverses epithelial-mesenchymal transition (EMT) via PI3K/AKT signaling pathway

• 细胞实验： Cell lines: MDA-MB-231 cells, HCC1937 cells, HCC1806 cells, MCF7 cells Concentrations: -- Incubation Time: 72 h Method: Cell proliferation is determined by the MTS assay. A total of 1-2×103 cells are plated in 100 μl medium in each well of a 96-well plate. After 24 h, PD-1/PD-L1 inhibitor 1 and ERK1/2 inhibitor are diluted to the desired concentrations in test medium (DMEM containing 1% fetal bovine serum) and added as single or as combined treatment in triplicate for 72 h.

• 动物实验： Animal Models: Male specific pathogen free BALB/c mice of hepatic metastatic colorectal cancer (CRC) model Dosages: 100 µg Administration: i.p.

• 参考文献：
  1. WO/2015/034820, COMPOUNDS USEFUL AS IMMUNOMODULATORS. 2. Bräutigam K, et al. Inhibitors of PD-1/PD-L1 and ERK1/2 impede the proliferation of receptor positive and triple-negative breast cancer cell lines. J Cancer Res Clin Oncol. 2021;147(10):2923-2933. 3. Shan, Feiyu et al. Inhibition to Epithelial-Mesenchymal Transition and Metastatic Potential In Colorectal Cancer Cell By Combination of Traditional Chinese Medicine Formulation Jiedu Sangen Decoction and PD-L1 Inhibitor. Integrative cancer therapies vol. 19 (2020): 1534735420972486.

• 溶解性： Soluble  in  DMSO、Ethanol、H2O

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.103 ml	10.514 ml	21.027 ml
  5 mM	0.421 ml	2.103 ml	4.205 ml
  10 mM	0.21 ml	1.051 ml	2.103 ml
  50 mM	0.042 ml	0.21 ml	0.421 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [3.7] Fu Shulin et al."Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways."VETERINARY RESEARCH.2024 Dec;55(1):1-17

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *