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S80452

Deracoxib

源叶(MedMol) 98%
  • 英文名:
  • Deracoxib
  • 别名:
  • 地拉考昔;地拉考昔-D3;Deracoxib;Benzenesulfonamide, 4-3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl-;4-(3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide;Dera
  • CAS号:
  • 169590-41-4
  • 分子式:
  • C17H14F3N3O3S
  • 分子量:
  • 397.372
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80452-25mg 98% ¥42.00元 10 - - - EA 加入购物车
源叶(MedMol) S80452-100mg 98% ¥89.00元 6 - - - EA 加入购物车
源叶(MedMol) S80452-500mg 98% ¥440.00元 3 - - - EA 加入购物车
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参考文献

质检证书(COA)

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  • 提示:详情请下载说明书。
  • 产品描述: Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).
  • 靶点: COX2;PDE4(Cell-free assay):3.6 μM;Apoptosis;COX
  • 细胞实验: Cell lines: MC4R-GLO cells Concentrations: 10 µM Incubation Time: 5 min Method: MC4R-GLO cells were plated in 12 well culture dishes in DMEM/F12 supplemented with 5% fetal bovine serum. Cells were incubated in serum-free medium over night before the experiment. Cells were then treated with the indicated concentration of α-MSH or vehicle for 5 min at 37°C in the presence or absence of 10 µM deracoxib or imperatorin. Dishes were then placed on ice and cells were scraped in 1x LDS-PAGE sample buffer with 100 mM DTT. Proteins were resolved by SDS-PAGE.
  • 参考文献:
    1. Millis DL, et al. Vet Ther. 2002, 3(4):453-64. 2. Pantel J, et al. Eur J Pharmacol. 2011, 660(1):139-47.
  • 溶解性: Soluble  in  DMSO、Ethanol
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.517 ml 12.583 ml 25.165 ml
    5 mM 0.503 ml 2.517 ml 5.033 ml
    10 mM 0.252 ml 1.258 ml 2.517 ml
    50 mM 0.05 ml 0.252 ml 0.503 ml
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