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• 产品描述： SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.

• 靶点： hGSK-3α:77.5 nM (IC50);hGSK-3β:77.5 nM (IC50);Apoptosis;GSK-3

• 参考文献：
  1. Coghlan MP, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol. 2000 Oct;7(10):793-803. 2. Pizarro JG, et al. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci. 2008 May-Jun;26(3-4):269-76. 3. MacAulay K, et al. Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. Eur J Biochem. 2003 Sep;270(18):3829-38.

• 溶解性： DMSO  :  100  mg/mL  (277.99  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.78 ml	13.9 ml	27.799 ml
  5 mM	0.556 ml	2.78 ml	5.56 ml
  10 mM	0.278 ml	1.39 ml	2.78 ml
  50 mM	0.056 ml	0.278 ml	0.556 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=11.467] Xiangwu Chen et al."Tumor lysates-constructed hydrogel to potentiate tumor immunotherapy."JOURNAL OF CONTROLLED RELEASE.2023 Jun;358:345

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *