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• 产品描述： AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.

• 靶点： EGFR:2 nM (IC50);ErbB2:6 nM (IC50);Apoptosis;EGFR;c-Fms;FLT;Bcr-Abl

• 体内研究：
  AEE788 efficiently inhibits growth factor-induced EGFR and ErbB2 phosphorylation in tumors for >72 h. AEE788 also inhibits VEGF-induced angiogenesis in a murine implant model. In mice treated with AEE788, tumor growth is inhibited by 54% at 21 days after the start of treatment compared with control mice

• 参考文献：
  1. Traxler P, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64(14):4931-4941. 2. Park et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11(5):1963-1973.

• 溶解性： DMSO  :  50  mg/mL  (113.49  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.27 ml	11.349 ml	22.697 ml
  5 mM	0.454 ml	2.27 ml	4.539 ml
  10 mM	0.227 ml	1.135 ml	2.27 ml
  50 mM	0.045 ml	0.227 ml	0.454 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *