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• 产品描述： SSR128129E is an orally available and allosteric FGFR inhibitor with an IC50 of 1.9 μM for FGFR1.

• 靶点： FGFR1:1.9 μM (IC50);FGFR2;FGFR3;FGFR4;FGFR

• 体内研究：
  Oral delivery of SSR128129E (30 mg/kg/day, from day 3) inhibits growth of orthotopic Panc02 tumors by 44% and delays growth of Lewis lung carcinoma. oral SSR128129E (30 mg/kg/day, from day 5) reduces tumor size and weight by 53% and 40%, respectively. SSR128129E inhibits the growth of subcutaneous CT26 colon tumors by 34% and of the multidrug resistant MCF7/ADR breast cancer xenograft model by 40%. SSR128129E reduces tumor invasiveness and metastasis of Panc02 tumor cells to peritoneal lymph nodes

• 参考文献：
  1. Bono F, et al. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell. 2013 Apr 15;23(4):477-88.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃;充氩;干燥

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.888 ml	14.438 ml	28.876 ml
  5 mM	0.578 ml	2.888 ml	5.775 ml
  10 mM	0.289 ml	1.444 ml	2.888 ml
  50 mM	0.058 ml	0.289 ml	0.578 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *