S81518 |
PX-478 |
源叶(MedMol) | 98% |
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- 产品描述:
PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier
- 靶点: HIF-1α;HIF/HIFProlyl-Hydroxylase; HIF; Autophagy
- 体内研究:
PX-478 is administered to mice with congenital HO (Nfatc1-Cre/caACVR1fl/fl) every other day starting from birth for 2 wk. Treated mice have significantly less ectopic bone at the ankle joints compared with mutant mice treated with vehicle (6.8 mm3 vs. 2.2 mm3, P<0.01)
- 参考文献:
1. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437. 2. Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.
- 溶解性: DMSO : 100 mg/mL (253.73 mM; Need ultrasonic) H2O : ≥ 35 mg/mL (88.81 mM)
- 保存条件: 2-8℃,氮气保存
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.537 ml 12.686 ml 25.372 ml 5 mM 0.507 ml 2.537 ml 5.074 ml 10 mM 0.254 ml 1.269 ml 2.537 ml 50 mM 0.051 ml 0.254 ml 0.507 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)