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• 产品描述： Clopidogrel thiolactone is an active metabolites containing thiols resulting from thionolactone transformation of clopidogrel (HY-15283). Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent

• 靶点： P2Y12 Receptor;P2YReceptor

• 体内研究：
  Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) has good biological availability and pharmacokinetic parameters

• 参考文献：
  1. Shan J, et, al. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent. J Med Chem. 2012 Apr 12;55(7):3342-52. 2. Hagihara K, et, al. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs. Xenobiotica. 2009 Mar;39(3):218-26.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.96 ml	14.801 ml	29.601 ml
  5 mM	0.592 ml	2.96 ml	5.92 ml
  10 mM	0.296 ml	1.48 ml	2.96 ml
  50 mM	0.059 ml	0.296 ml	0.592 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=1.8] Xiao Tang et al."Development and validation of a sensitive LC-MS/MS method for simultaneous analysis of clopidogrel and simvastatin and their main metabolites in beagles: Application to pharmacokinetic drug interactions."BIOMEDICAL CHROMATOGRAPHY.2023 Aug

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *