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• 产品描述： JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively

• 靶点： IC50: 2 nM (FAAH), 4 nM (MAGL);FAAH; Lipase; Autophagy

• 体外研究：
  JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively). JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays

• 体内研究：
  JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. Animal Model: Male C57BL/6J mice Dosage: 20 mg/kg Administration: Intraperitoneal injection Result: Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.

• 参考文献：
  1. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5. 2. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.307 ml	11.535 ml	23.07 ml
  5 mM	0.461 ml	2.307 ml	4.614 ml
  10 mM	0.231 ml	1.154 ml	2.307 ml
  50 mM	0.046 ml	0.231 ml	0.461 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *