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• 产品描述： Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus

• 靶点： SGLT2;SGLT

• 体内研究：
  Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats

• 参考文献：
  1. Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60. 2. Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56. 3. Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C;充氩

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.289 ml	11.445 ml	22.89 ml
  5 mM	0.458 ml	2.289 ml	4.578 ml
  10 mM	0.229 ml	1.144 ml	2.289 ml
  50 mM	0.046 ml	0.229 ml	0.458 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *