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S82597

BEPOTASTINE

源叶(MedMol) 98%
  • 英文名:
  • BEPOTASTINE
  • 别名:
  • 贝托斯汀;4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸;贝托司汀;4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID;BEPOTASTINE;1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-;betot
  • CAS号:
  • 125602-71-3
  • 分子式:
  • C21H25ClN2O3
  • 分子量:
  • 388.888
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S82597-5mg 98% ¥300.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S82597-50mg 98% ¥1090.00元 6 - - - EA 加入购物车
源叶(MedMol) S82597-100mg 98% ¥1760.00元 4 - - - EA 加入购物车
源叶(MedMol) S82597-500mg 98% ¥6000.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 产品描述: Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research
  • 靶点: Histamine H1 Receptor;Others; HistamineReceptor
  • 体内研究:
    Bepotastine (10 g/L; eye drop; 3 times at intervals of 20 min in one eye) demonstrates significant inhibition of PAF-induced conjunctival eosinophil infiltration. Bepotastine (3 mg/kg; p.o.; once) suppresses scratching behavior to a frequency of 59.0 and a duration of 14.57 seconds, which are almost the same levels compares with the control. Bepotastine (10 mg/kg; p.o.; once) significantly suppresses serum LTB 4 levels to 711.3 pg/mL at 1 h and 858.8 pg/mL at 2 h in NC/Nga mice with a rash
  • 参考文献:
    1. Kida T, et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91(1):8 2. Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811(18)30186-5. 3. Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145(4):277-82. 4. Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26(10):2329-38.
  • 溶解性: Soluble  in  H2O、DMSO
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.571 ml 12.857 ml 25.714 ml
    5 mM 0.514 ml 2.571 ml 5.143 ml
    10 mM 0.257 ml 1.286 ml 2.571 ml
    50 mM 0.051 ml 0.257 ml 0.514 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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